Monday, July 21, 2008

AHFS DI Essentials: What's New in July 2008

New Monographs

  • Antithymocyte Globulin (Rabbit): Antithymocyte globulin (rabbit) (ATG [rabbit]); rabbit-derived polyclonal antibody preparation; immunosuppressive agent.
  • Atropine: Mydriatic and cycloplegic; naturally occurring tertiary amine antimuscarinic.
    Estazolam: Benzodiazepine, sedative and hypnotic.
  • Guanfacine: Phenylacetyl-guanidine derivative hypotensive agent; selective α2-adrenergic agonist.
  • Hydroquinone: Depigmenting agent; structurally related to monobenzone.
    Phenelzine: Hydrazine-derivative, nonselective monoamine oxidase (MAO) inhibitor antidepressant.
  • Sodium Chloride: Source of essential sodium and chloride ions.
  • Tranylcypromine: Non-hydrazine derivative, nonselective monoamine oxidase (MAO) inhibitor antidepressant; structurally similar to amphetamine.

Revised Monographs

  • Abacavir: Antiretroviral; nucleoside reverse transcriptase inhibitor (NRTI).
  • Adalimumab: Biologic response modifier and disease-modifying antirheumatic drug (DMARD); a recombinant DNA-derived human immunoglobulin G1 (IgG1) monoclonal antibody specific for human tumor necrosis factor (TNF; TNF-α).
  • Azacitidine: Antineoplastic agent; a synthetic pyrimidine nucleoside analog of cytidine.
    Darbepoetin Alfa: Biosynthetic (recombinant DNA origin) form of the glycoprotein hormone erythropoietin, a hematopoietic agent that principally affects erythropoiesis.
  • Darunavir: Antiretroviral; HIV protease inhibitor (PI).
  • Didanosine: Antiretroviral; nucleoside reverse transcriptase inhibitor (NRTI).
  • Etanercept: Biologic response modifier and disease-modifying antirheumatic drug (DMARD); a recombinant DNA-derived human immunoglobulin G1 (IgG1) monoclonal antibody specific for human tumor necrosis factor (TNF; TNF-α).
  • Formoterol: Bronchodilator; a relatively selective, long-acting β2-adrenergic agonist.
  • Metformin: Antidiabetic agent; a biguanide, chemically and pharmacologically unrelated to sulfonylurea antidiabetic agents.
  • Montelukast: Antiasthmatic agent; leukotriene modifier.
  • Natalizumab: Biologic response modifier; a recombinant humanized anti-α4-integrin monoclonal antibody.
  • Oseltamivir: Antiviral; neuraminidase inhibitor; sialic acid analog.
  • Sargramostim: Biosynthetic hematopoietic agent that affects the proliferation and differentiation of a variety of hematopoietic progenitor cells; a yeast-derived (Saccharomyces cerevisiae) recombinant human granulocyte-macrophage colony-stimulating factor (rHuGM-CSF).
  • Tiotropium: Bronchodilator; a synthetic quaternary ammonium antimuscarinic agent.
  • Zoledronic Acid: Synthetic bisphosphonate; bone resorption inhibitor.